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Lexicon Announces Publication Of Results From The Phase 2 Trial Of LX1031 In Patients With Irritable Bowel Syndrome In Journal Of Gastroenterology

Source: Medical News Today

Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), a biopharmaceutical company focused on discovering breakthrough treatments for human disease, announced today that results from the Phase 2 clinical trial of LX1031 in patients with non-constipating irritable bowel syndrome (IBS) were published earlier this week in the August 2011 edition of the journal Gastroenterology. The issue also included an expert editorial discussing the study, its implications and the potential utility of this mechanism of action in gastrointestinal disease.

Results of the Phase 2 study showed that the tryptophan hydroxylase inhibitor, LX1031, was well tolerated and provided clinical benefit to patients with non-constipating IBS, showing improvements in a global assessment of adequate relief from IBS pain and discomfort and in stool consistency. Notably, symptom relief correlated with reduced levels of 5-HIAA, a biomarker of serotonin production.


Study Published In World Journal Of Gastroenterology Shows Potential For MicroRNAs To Predict Gastric Cancer Recurrence

Source: Medical News Today

Rosetta Genomics, Ltd. (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostics, announces that results from a joint study by researchers at the Institutes of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Hospital and Golda-Hasharon Hospital in Petach-Tikva, Israel show that in post-resection gastric cancer patients microRNAs may serve to predict the risk of recurrence.

The study, entitled “microRNAs as a potential prognostic factor in gastric cancer,” was published online September 21, 2011, and is set to appear in the print edition of the World Journal of Gastroenterology.


Source Of Norovirus Outbreak Traced To Reusable Grocery Bag

Source: Medical News Today

Oregon investigators recently mapped the trail of an outbreak of a nasty stomach bug among participants in a girls’ soccer tournament to a reusable open top grocery bag stored in a hotel bathroom. Their findings, which illustrate the role that inanimate objects can play in spreading norovirus infection, appear in The Journal of Infectious Diseases.

Noroviruses are a leading cause of gastroenteritis worldwide and the most common cause of foodborne outbreaks in the United States. Highly contagious, even in low concentrations, the viruses spread efficiently from feces and vomit by direct contact or by indirect transmission from viral contamination of surfaces. In October 2010, a cluster of gastroenteritis that appeared in a group of people with no apparent direct physical contact with a pathogen challenged investigators to find the cause and take appropriate control measures.


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